期刊簡(jiǎn)介預(yù)計(jì)審稿時(shí)間： 較慢,6-12周

Nucleotides and nucleosides are primitive biological molecules that were utilized early in evolution both as intracellular energy sources and as extracellular signalling molecules. ATP was first identified as a neurotransmitter and later as a co-transmitter with all the established neurotransmitters in both peripheral and central nervous systems. Four subtypes of P1 (adenosine) receptors, 7 subtypes of P2X ion channel receptors and 8 subtypes of P2Y G protein-coupled receptors have currently been identified. Since P2 receptors were first cloned in the early 1990’s, there is clear evidence for the widespread distribution of both P1 and P2 receptor subtypes in neuronal and non-neuronal cells, including glial, immune, bone, muscle, endothelial, epithelial and endocrine cells.

核苷酸和核苷是原始的生物分子，在進(jìn)化早期既用作細(xì)胞內(nèi)能量來(lái)源，又用作細(xì)胞外信號(hào)分子。ATP 最初被確定為一種神經(jīng)遞質(zhì)，后來(lái)被確定為外周和中樞神經(jīng)系統(tǒng)中所有已確定的神經(jīng)遞質(zhì)的共同遞質(zhì)。目前已確定了四種 P1（腺苷）受體亞型、七種 P2X 離子通道受體亞型和八種 P2Y G 蛋白偶聯(lián)受體亞型。自 20 世紀(jì) 90 年代初首次克隆出 P2 受體以來(lái)，有明確證據(jù)表明 P1 和 P2 受體亞型廣泛分布于神經(jīng)元和非神經(jīng)元細(xì)胞中，包括神經(jīng)膠質(zhì)細(xì)胞、免疫細(xì)胞、骨骼細(xì)胞、肌肉細(xì)胞、內(nèi)皮細(xì)胞、上皮細(xì)胞和內(nèi)分泌細(xì)胞。

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