期刊簡介預計審稿時間： 偏慢,4-8周

Mutation Research (MR) provides a platform for publishing all aspects of DNA mutations and epimutations, from basic evolutionary aspects to translational applications in genetic and epigenetic diagnostics and therapy. Mutations are defined as all possible alterations in DNA sequence and sequence organization, from point mutations to genome structural variation, chromosomal aberrations and aneuploidy. Epimutations are defined as alterations in the epigenome, i.e., changes in DNA methylation, histone modification and small regulatory RNAs.

MR publishes articles in the following areas:

Of special interest are basic mechanisms through which DNA damage and mutations impact development and differentiation, stem cell biology and cell fate in general, including various forms of cell death and cellular senescence.

The study of genome instability in human molecular epidemiology and in relation to complex phenotypes, such as human disease, is considered a growing area of importance.

Mechanisms of (epi)mutation induction, for example, during DNA repair, replication or recombination; novel methods of (epi)mutation detection, with a focus on ultra-high-throughput sequencing.

Landscape of somatic mutations and epimutations in cancer and aging.

Role of de novo mutations in human disease and aging; mutations in population genomics.

Interactions between mutations and epimutations.

The role of epimutations in chromatin structure and function.

Mitochondrial DNA mutations and their consequences in terms of human disease and aging.

Novel ways to generate mutations and epimutations in cell lines and animal models.

突變研究 (MR) 提供了一個平臺，用于發(fā)布 DNA 突變和表觀突變的各個方面，從基本的進化方面到遺傳和表觀遺傳診斷和治療中的轉化應用。突變被定義為 DNA 序列和序列組織的所有可能改變，從點突變到基因組結構變異、染色體畸變和非整倍性。表觀突變被定義為表觀基因組的改變，即 DNA 甲基化、組蛋白修飾和小調節(jié) RNA 的變化。

MR 在以下領域發(fā)表文章：

特別令人感興趣的是 DNA 損傷和突變影響發(fā)育和分化、干細胞生物學和細胞命運的基本機制，包括各種形式的細胞死亡和細胞衰老。

人類分子流行病學中基因組不穩(wěn)定性的研究以及與人類疾病等復雜表型的關系被認為是一個日益重要的領域。

（表觀）突變誘導機制，例如在 DNA 修復、復制或重組過程中；檢測（表觀）突變的新方法，重點是超高通量測序。

癌癥和衰老中的體細胞突變和表觀突變概況。

新生突變在人類疾病和衰老中的作用；群體基因組學中的突變。

突變和表觀突變之間的相互作用。

表觀突變在染色質結構和功能中的作用。

線粒體 DNA 突變及其對人類疾病和衰老的影響。

在細胞系和動物模型中產生突變和表觀突變的新方法。

《Mutation Research-fundamental And Molecular Mechanisms Of Mutagenesis》(突變研究-突變發(fā)生的基本和分子機制)編輯部通訊方式為ELSEVIER SCIENCE BV, PO BOX 211, AMSTERDAM, NETHERLANDS, 1000 AE。如果您需要協(xié)助投稿或潤稿服務，您可以咨詢我們的客服老師。我們專注于期刊咨詢服務十年，熟悉發(fā)表政策，可為您提供一對一投稿指導，避免您在投稿時頻繁碰壁，節(jié)省您的寶貴時間，有效提升發(fā)表機率，確保SCI檢索（檢索不了全額退款）。我們視信譽為生命，多方面確保文章安全保密，在任何情況下都不會泄露您的個人信息或稿件內容。